G - Physics – 01 – N
Patent
G - Physics
01
N
G01N 33/566 (2006.01) A61K 39/395 (2006.01) A61P 35/00 (2006.01) G01N 33/543 (2006.01) G01N 33/574 (2006.01) G01N 33/68 (2006.01) G01N 33/58 (2006.01)
Patent
CA 2720294
The disclosure relates to methods for identifying a subject having elevated CD200 levels and/or comprising cells overexpressing CD200, the method comprising the step of assaying a biological fluid from the subject to determine a level of soluble CD200, wherein a level above control indicates the subject has elevated CD200 levels. Diagnostic methods, methods of monitoring prognosis and methods of medical treatment relating to CD200 associated medical conditions are also provided. The disclosure also provides assays and kits useful in the diagnosis of a medical condition associated with elevated CD200 and/or comprising cells overexpressing CD200.
La présente invention concerne des procédés permettant didentifier un sujet présentant des niveaux élevés de CD200 et/ou ayant des cellules surexprimant CD200, le procédé comprenant lanalyse dun fluide biologique prélevé du sujet pour déterminer un niveau de CD200 soluble, un niveau supérieur à un groupe témoin indiquant que le sujet présente des niveaux élevés de CD200. Linvention concerne également des procédés de diagnostic, des procédés de suivi de pronostic et des procédés de traitement médical concernant des conditions médicales associées au CD200. Linvention concerne en outre des dosages et des trousses utiles dans le diagnostic dune condition médicale associée à des niveaux élevés de CD200 et/ou impliquant des cellules de surexpression de CD200.
Gorczynski Reginald M.
Wong Karrie Ka Wai
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Trillium Therapeutics Inc.
University Health Network
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