Assay for the diagnosis of schizophrenia

G - Physics – 01 – N

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G01N 33/543 (2006.01) G01N 33/567 (2006.01) G01N 33/569 (2006.01)

Patent

CA 2184602

An immunological assay for the diagnosis of schizophrenia in an individual is described. The assay comprises the following steps: (a) a blood sample, a platelet-containing fraction of a blood sample, or a fraction containing platelet-associated antibodies (PAA) shed from the platelets is obtained from an individual; (b) the sample is contacted with platelet antigens fixed to a solid support, and subsequently with an antibody detection system; and (c) the binding pattern of the PAA to the platelet antigens is determined and compared to the binding pattern of a sample obtained from a normal individual. A difference in patterns indicates that the individual has a high likelihood of having schizophrenia. The assay is capable of differentiating schizophrenia from dementia, as well as from Idiopathic Thrombocytopenia Purpura (ITP), an autoimmune disease directed against a platelet antigen.

La présente invention concerne un essai destiné au diagnostic de la schizophrénie chez un sujet. L'essai se déroule en plusieurs opérations: (a) prélèvement d'un échantillon de sang, ou séparation de la fraction thrombocytaire d'un échantillon de sang, ou encore séparation d'une fraction contenant des anticorps associés aux thrombocytes ou "PAA" à partir d'un échantillon de sang prélevé chez un sujet; (b) mise en contact de l'échantillon, d'abord avec des antigènes thrombocytaires fixés sur un support solide, puis avec un système de détection d'anticorps; et (c) détermination des antigènes thrombocytaires du PAA et comparaison par rapport à la structure de liaison d'un échantillon prélevé chez un sujet témoin. Une différence structurelle est l'indice d'une forte probabilité de schizophrénie chez le sujet. L'essai permet de distinguer entre schizophrénie et démence, de même qu'entre thrombocythopénie chronique idiopathique et affections auto-immunes dirigées contre un antigène thrombocytaire.

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