C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 9/88 (2006.01) C07K 7/08 (2006.01) G01N 33/53 (2006.01) G01N 33/68 (2006.01)
Patent
CA 2324380
The invention concerns peptides which bind antibodies that are found in elevated levels in body fluids of schizophrenic patients and are found at a lower level or not found at all in body fluids of non- schizophrenic individuals. Using a computerized program, the antigenic epitope of the peptides of the invention is predicted as having a core of hydrophobic amino acids which is surrounded by positively charged amino acids. The peptides of the invention are useful in the diagnosis of schizophrenia in an individual.
La présente invention concerne des peptides qui se lient à des anticorps présents à des taux élevés dans des liquides organiques d'individus schizophrènes, les liquides organiques d'individus non schizophrènes présentant des taux nul ou faible de ces anticorps. Un programme d'ordinateur permet de prédire que l'épitope antigénique des peptides de la présente invention présente un noyau d'acides aminés hydrophobes entouré d'acides aminés chargés positivement. Les peptides de l'invention servent utilement à diagnostiquer la schizophrénie chez un individu.
Deckmann Michael
Shinitzky Meir
Smart & Biggar
Yeda Research And Development Co. Ltd.
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