Assay kit

Details Assay kit Assay kit

G - Physics

01

N

G01N 33/577 (2006.01) G01N 33/566 (2006.01) G01N 33/68 (2006.01) G01N 33/94 (2006.01)

Patent

CA 2169162

A new method of measuring blood levels of immunophilin-binding pharmaceuticals; e.g., cyclosporins, rapamycins, and FK506 compounds, is provided, comprising the novel step of displacing the pharmaceutical from its immunophilin by using a binding competitor, thereby eliminating the need for an extraction step and enhancing the simplicity and accuracy of the assay. Assay kits comprising a binding competitor and a receptor, e.g., a monoclonal antibody, which binds to the pharmaceutical but not significantly to the binding competitor, are also provided, as are new uses of immunophilin-binding compounds as binding competitors in such assays.

L'invention se rapporte à un nouveau procédé de détermination des taux sanguins de produits pharmaceutiques fixant l'immunophiline, tels que les cyclosporines, les rapamycines et les composés de FK506. Ce procédé comprend une nouvelle étape consistant à déplacer le produit pharmaceutique provenant de l'immunophiline à l'aide d'un compétiteur de liaison, ce qui élimine une étape d'extraction et contribue à simplifier davantage et améliorer le niveau de précision du dosage. Les coffrets de dosage comprennent un compétiteur de liaison et un récepteur, tel qu'un anticorps monoclonal, qui se fixe au produit pharmaceutique, mais pas de manière significative au compétiteur de liaison. L'invention se rapporte également à de nouvelles utilisations des composés fixant l'immunophiline.

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