Assay method for alzheimer's disease

Details Assay method for alzheimer's disease Assay method for alzheimer's disease

A - Human Necessities

61

K

A61K 49/00 (2006.01) A61K 38/00 (2006.01) A61K 39/395 (2006.01) A61P 25/28 (2006.01) C07K 16/00 (2006.01) C07K 16/18 (2006.01) G01N 33/53 (2006.01) G01N 33/564 (2006.01) G01N 33/566 (2006.01) G01N 33/567 (2006.01) G01N 33/68 (2006.01)

Patent

CA 2457145

A diagnostic test for preclinical and clinical Alzheimer's disease is based on plasma levels of A.beta.40, A.beta.42, their ratio, or their rate of entry following administration of antibodies that sequester A.beta.. Alterations of any of these parameters from control values identifies preclinical or clinical Alzheimer's disease.

L'invention concerne un examen diagnostique complémentaire destiné à la maladie d'Alzheimer préclinique et clinique. Cet examen se base sur des niveaux de plasma de A.beta.¿40?, A.beta.¿42?, sur leur rapport ou sur leur taux d'entrée après administration d'anticorps qui séquestrent A.beta.. Des modifications d'un de ces paramètres à partir des valeurs témoins identifient la maladie d'Alzheimer préclinique ou clinique.

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