G - Physics – 01 – N
Patent
G - Physics
01
N
167/44
G01N 33/543 (2006.01) G01N 33/53 (2006.01)
Patent
CA 1111346
ABSTRACT OF THE DISCLOSURE A new surface immunoassay method is performed with two test surfaces. The method is used where serum samples may contain both an antibody for which it is desirable to test, and also competing sera constituents which may be present in indeterminate amounts. In accordance with the method, two dif- ferent test surfaces are contacted with the same serum sample, and preferably the same aliquot of the serum. The first sur- face is treated to bind a broad spectrum of serum components including both the component to be tested for and also the com- peting components. The second surface is designed to bind the competing components but no substantial amount of the serum com- ponent to be tested for. The immunoassay is conducted with a labeled antibody, and quantitative measurement of the immuno- assay is obtained by detecting the quantitative difference in the amount of labeled antibody on the two surfaces which have been subjected to the same serum sample. The method has utility in detecting a wide variety of antibodies of both the immuno- globulin G and immunoglobulin M classes, including antibodies for rubella, treponema, herpes simplex virus, cytomegalovirus and toxoplasma.
314577
Burgett Michael W.
Harte Richard A.
International Diagnostic Technology Inc.
Smart & Biggar
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