Assay of isomerised and/or optically inverted proteins

Details Assay of isomerised and/or optically inverted proteins Assay of isomerised and/or optically inverted proteins

G - Physics

01

N

G01N 33/68 (2006.01) C07K 16/18 (2006.01) G01N 33/53 (2006.01) G01N 33/543 (2006.01)

Patent

CA 2392649

A method of immuno-assay comprises immunologically measuring in a biological sample the amount of an isomerised or optically inverted non-collagen protein derived from cartilage or of one or more isomerised or optically inverted fragments from such a protein. The method may determine the amount of at least one *Asx or *Glx containing protein or protein fragment in said biological sample, wherein *Asx is .alpha.D Asp or Asn or is .beta.L or .beta.D Asp and *Glx is .alpha.D Glu or Gln or .gamma.L or .gamma.D Glu. The protein may be aggrecan, CLP, COMP, or CILP or said fragment is a fragment of aggrecan, CLP, COMP, or CILP.

L'invention se rapporte à un procédé de dosage immunologique consistant à mesurer de manière immunologique, dans un échantillon biologique, la quantité d'une protéine non-collagène isomérisée ou optiquement inversée, dérivée de cartilage, ou d'un ou de plusieurs fragments isomérisés ou optiquement inversés d'une telle protéine. Ledit procédé peut permettre de déterminer la quantité dans ledit échantillon biologique d'au moins une protéine ou d'un fragment de protéine contenant *Asx ou *Glx, où *Asx est .alpha.D Asp ou Asn ou est .beta.L or .beta.D Asp et *Glx est .alpha.D Glu ou Gln ou .gamma.L ou .gamma.D Glu. Cette protéine peut être aggrecan, CLP, COMP ou CILP ou bien ledit fragment est un fragment d'aggrecan, de CLP, de COMP ou de CILP.

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