Assay systems for neurotrophin activity

Details Assay systems for neurotrophin activity Assay systems for neurotrophin activity

C - Chemistry, Metallurgy

12

N

C12N 15/54 (2006.01) A61K 38/18 (2006.01) A61K 38/45 (2006.01) C07K 14/71 (2006.01) C07K 14/82 (2006.01) C12N 1/21 (2006.01) C12N 5/10 (2006.01) C12N 9/12 (2006.01) C12N 15/10 (2006.01) C12N 15/18 (2006.01) C12Q 1/00 (2006.01) C12Q 1/02 (2006.01) G01N 33/50 (2006.01) G01N 33/566 (2006.01) G01N 33/573 (2006.01) G01N 33/68 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2109100

2109100 9218149 PCTABS00016 The present invention provides for assay systems that may be used to detect and/or measure neurotrophin activity or to identify agents that exhibit neurotrophin-like activity. It is based, at least in part, on the discovery that the trkB proto-oncogene encodes a tyrosine kinase receptor that may serve as a functional binding protein for BDNF and NT-3. The present invention also provides for diagnostic and therapeutic methods based on the interaction between BDNF and/or NT-3 and trkB, and for a number of orphan receptor molecules.

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