Assays, antibodies, and standards for detection of oxidized...

Details Assays, antibodies, and standards for detection of oxidized... Assays, antibodies, and standards for detection of oxidized...

C - Chemistry, Metallurgy

12

N

C12N 5/12 (2006.01) C07K 16/18 (2006.01) C07K 16/44 (2006.01) C12P 21/08 (2006.01) G01N 33/577 (2006.01) G01N 33/92 (2006.01) G01N 33/96 (2006.01)

Patent

CA 2294355

Immunoassays for malondialdehyde-modified low density lipoprotein (MDA- modified LDL) and oxidized low density lipoprotein (OxLDL), monoclonal antibodies (and the cell lines for them) for use in the assays, and a storage-stable standard (which may be used as a calibrator and/or control) are disclosed. MDA-modified LDL and OxLDL are implicated in atherosclerosis and its etiology.

L'invention concerne des immunodosages destinés à des lipoprotéines de basse densité, modifiées par le malondialdéhyde (LDL modifiée par MDA), ainsi que des lipoprotéines de basse densité, oxydées (OxLDL); elle concerne également des anticorps monoclonaux (et les lignées cellulaires qui leur sont destinées) utiles dans les dosages, ainsi qu'un étalon stable pendant son stockage (et que l'on peut utiliser en tant qu'étalon de référence et/ou témoin). Ces LDL modifiées par MDA et OxLDL sont impliquées dans l'athérosclérose et dans l'étiologie de celle-ci.

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