Assays for alternative lengthening of telomeres

Details Assays for alternative lengthening of telomeres Assays for alternative lengthening of telomeres

C - Chemistry, Metallurgy

12

N

C12N 15/65 (2006.01)

Patent

CA 2418352

Assays are provided for measuring alternative lengthening of telomeres (ALT) activity in eukaryotic cells. Also provided are assays for identifying compounds that affect ALT activity. Nucleid acid constructs and host cells comprising the nucleic acid constructs are also provided.

L'invention se rapporte à des analyses permettant de quantifier une activité d'allongement variable de télomères (ALT) dans des cellules eucaryotes. L'invention se rapporte également à des analyses permettant d'identifier des composés qui modifient l'activité ALT. L'invention se rapporte en outre à des constructions d'acides nucléiques et à des cellules hôtes comportant ces constructions d'acides nucléiques.

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