Assays for chemotherapeutic agents

Details Assays for chemotherapeutic agents Assays for chemotherapeutic agents

G - Physics

01

N

150/13, 167/46

G01N 33/48 (2006.01) A61K 49/00 (2006.01) C12Q 1/18 (2006.01) G01N 33/50 (2006.01)

Patent

CA 1265443

Abstract of the Disclosure A new method of assaying cells for sensitivity to therapeutic agents is disclosed consisting of the steps of: encapsulating the cells within a semipermeable membrane; inoculating the encapsulated cells into a living host animal; exposing the cells to the therapeutic agent before or after inoculation; retrieving the microcapsules from the host animal; and, measuring changes in the encapsulated cells to provide an indication of cytotoxic effects. The inoculated, encapsulated cells provide an ideal environment that can mimic in vivo growth conditions under which the efficacy of various of chemotherapeutic agents can be tested.

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