Assays for inhibitors of leukocyte adhesion

Details Assays for inhibitors of leukocyte adhesion Assays for inhibitors of leukocyte adhesion

G - Physics

01

N

G01N 33/566 (2006.01) C07K 14/705 (2006.01) C07K 16/28 (2006.01) G01N 33/543 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2109212

2109212 9219761 PCTABS00017 The present invention provides novel assays for determining the ability of a test compound to inhibit intercellular adhesion mediated by a selectin receptor, such as the LHR. The assays involve contacting the test compound with the receptor and an isolated receptor-binding agent. The receptor-binding agent is a sulfated polysaccharide, a sulfated glycolipid, or a compound comprising the extracellular region of an endothelial cell surface glycoprotein. Also provided are compositions comprising a compound comprising the extracellular region of an endothelial cell surface protein, which is specifically recognized by lymphocyte homing receptors.

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