Assays for modulators of parkin activity using novel substrates

Details Assays for modulators of parkin activity using novel substrates Assays for modulators of parkin activity using novel substrates

C - Chemistry, Metallurgy

12

Q

C12Q 1/25 (2006.01) G01N 33/50 (2006.01)

Patent

CA 2677231

The invention provides in vitro and cell-based assays for parkin activity, in which parkin- mediated ubiquitination of the S5a subunit of the 26S proteasome is measured, or ubiquitination of troponin 1. The assays may be used to screen for agents that modulate parkin protein ligase activity.

L'invention concerne des dosages in vitro et à base de cellules pour l'activité de la parkine, selon lesquels l'ubiquitination induite par la parkine de la sous-unité S5a du protéasome 26S est mesurée ou l'ubiquitination de la troponine 1. Les dosages peuvent être utilisés pour cribler des agents qui modulent l'activité de la parkine protéine ligase.

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