C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/68 (2006.01) C07H 19/00 (2006.01) C07H 21/00 (2006.01)
Patent
CA 2617063
Nucleic acid amplification assays for mutations to two short sections of the fungal gene FKS1. Mutations in these target sequences have been shown to correlate with resistance to echinocandin-class drugs. Assays may include detection by sequencing or by labeled hybridization probes. Also, primers, probes and reagent kits for performing such assays.
La présente invention concerne des analyses d'amplification d'acides nucléiques permettant de détecter des mutations dans deux portions courtes du gène fongique FKS1. Les mutations dans ces séquences cibles ont un rapport avec la résistance à des médicaments de la classe des échinocandines. Ces analyses peuvent comprendre la détection par séquençage ou par sondes d'hybridation étiquetées. Cette invention concerne également des trousses d'amorces, de sondes et de réactifs permettant d'effectuer ces analyses.
Douglas Cameron M.
Kahn Jennifer Nielsen
Kelly Rosemarie
Parent Stephen A.
Park Steven
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Merck & Co. Inc.
Merck Sharp & Dohme Corp.
University Of Medicine And Dentistry Of New Jersey
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