C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/57 (2006.01) A61K 38/48 (2006.01) C12N 9/50 (2006.01) C12N 9/52 (2006.01) C12N 9/64 (2006.01) C12N 15/18 (2006.01) C12N 15/31 (2006.01) C12P 21/02 (2006.01) C12Q 1/37 (2006.01) G01N 33/53 (2006.01) G01N 33/68 (2006.01)
Patent
CA 2447040
The present invention relates to proteins of the conserved Rhomboid family, which are involved in various signalling pathways within cells. Rhomboid proteins are found to possess a novel serine protease activity which cleaves within the transmembrane domain of a polypeptide substrate. Methods and uses of this activity are provided.
La présente invention concerne des protéines conservées de la famille des rhomboïdes intervenant dans diverses voies de signalisation des cellules. On a découvert que ces protéines rhomboïdes possèdent une nouvelle activité sérine protéase permettant un clivage dans le domaine transmembranaire d'un substrat polypeptidique. L'invention concerne également des méthodes et des utilisations associées à cette activité.
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Medical Research Council
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