Assays, methods and means for modulating nuclear localisation

Details Assays, methods and means for modulating nuclear localisation Assays, methods and means for modulating nuclear localisation

G - Physics

01

N

G01N 33/68 (2006.01) C12Q 1/48 (2006.01)

Patent

CA 2338837

CBP histone acetyltransferase acetylates Importin .alpha., affecting ability of Importin .alpha. to translocate into the nucleus and import a cargo protein. Assays identify substances which modulate interaction between CBP and Importin .alpha. and acetylation of Importin .alpha. by CBP. Substances identified in the assays are useful for treatment of disorders in which Importin .alpha. plays a role.

L'histone acétyltransférase CBP acétyle l'Importine .alpha., affectant la capacité de l'Importine .alpha. de se transférer dans le noyau et d'y importer une protéine porteuse. Des dosages permettent d'identifier des substances qui modulent l'interaction entre la protéine CBP et l'Importine .alpha. ainsi que l'acétylation de l'Importine .alpha. par la protéine CBP. Les substances identifiées dans ces dosages sont utiles dans le traitement de troubles dans lesquels l'Importine .alpha. joue un rôle.

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