C - Chemistry – Metallurgy – 12 – P
Patent
C - Chemistry, Metallurgy
12
P
167/139, 167/37,
C12P 21/08 (2006.01) C07K 14/47 (2006.01) C07K 16/18 (2006.01) C12N 15/85 (2006.01) C12Q 1/68 (2006.01) G01N 33/564 (2006.01) G01N 33/577 (2006.01) G01N 33/68 (2006.01) G01N 33/74 (2006.01)
Patent
CA 2013389
ASSAYS OF COUP-TRANSCRIPTION FACTOR INTERACTIONS IN MAMMALIAN SYSTEMS Abstract of the Disclosure Multiple methods for measuring the COUP-TF system, including: a method to measure the level of COUP-TF by combining antibodies with biological samples and measuring the resultant antibody/COUP-TF complex; the binding of COUP-TF to promoters by combining biological samples with COUP-TF binding oligonucleotides and measuring the resultant complex or gene synthesis; and a method to measure COUP-TF inducable promoters by combining native COUP-TF with nuclear extracts of biological samples and measuring the resultant complexes. The methods when applied to human biological samples can detect diabetes due to COUP-TF or promoter defects. In addition to the methods for measuring the COUP-TF system and associated diseases, there are also the polyclonal and monoclonal antibodies necessary for the methods. These bind to at least one immunoreactive site on COUP-TF. Furthermore, there is a DNA clone containing the genetic coding regions of the COUP-TF protein. 9000G
O'malley Bert W.
Tsai Ming-Jer
Tsai Sophia Y.
Wang Lee-Ho
Baylor College Of Medicine
Borden Ladner Gervais Llp
LandOfFree
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