Assays therapeutic methods and means

Details Assays therapeutic methods and means Assays therapeutic methods and means

G - Physics

01

N

G01N 33/68 (2006.01) C07K 14/47 (2006.01) C12N 9/12 (2006.01) C12Q 1/48 (2006.01) G01N 33/574 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2296416

The interaction of ATM and related protein kinases such as ATR and DNA-PK with p53 is disclosed, in particular the phosphorylation of Ser15 and Thr18 by these proteins. The activity of the proteins is shown to increase in the presence of DNA. Assays for modulators of phosphorylation by the interaction between the proteins and p53 or other proteins having similar phosphorylation sites are provided. Methods of purifying ATM or ATR employing DNA or NTA are also disclosed.

La présente invention concerne l'interaction des ATM avec les kinases protéiques correspondantes telles que les ATR, ADN-PK et les p53, en particulier la phosphorilation des Ser15 et thr18 par ces protéines. Par ailleurs, l'activité des protéines semble augmenter en présence de l'ADN. Cette invention s'intéresse également à des techniques se rapportant aux modulateurs de la phosphorilation par l'interaction entre les protéines et les p53, ou d'autres protéines possédant des sites de phosphorilation similaires. Des méthodes de purification des ATM et ATR utilisant l'ADN ou Le NTA sont également décrites.

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