Assays to evaluate chemotherapeutic effectiveness of drugs

Details Assays to evaluate chemotherapeutic effectiveness of drugs Assays to evaluate chemotherapeutic effectiveness of drugs

C - Chemistry, Metallurgy

12

Q

C12Q 1/48 (2006.01) C12Q 1/02 (2006.01) C12Q 1/68 (2006.01) G01N 33/573 (2006.01)

Patent

CA 2225997

In vitro assays which respond to signal pathway modulating compounds in transformed cells are described. By measuring the effect of candidate drugs on specific kinase targets, successful candidates can be screened. Tumor biopsies can be assayed for susceptibility to treatment with a particular drug using similar assays. The VL30 controlled expression of a reporter gene can also be used in screening assays for both inhibitors and stimulators of cell proliferation.

On décrit des titrages in vitro qui réagissent à des composés de modulation de voies de signalisation dans des cellules transformées. En mesurant l'effet de médicaments candidats sur des cibles kinases spécifiques, on peut cribler des candidats à succès. On peut titrer la sensibilité de biopsies tumorales au traitement réalisé avec un médicament donné en utilisant des titrages similaires. L'expression modulée par VL30 d'un gène reporter peut également être utilisée dans des méthodes de criblage concernant tant des inhibiteurs que des stimulants de prolifération cellulaire.

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