G - Physics – 01 – N
Patent
G - Physics
01
N
G01N 33/72 (2006.01) G01N 33/53 (2006.01) G01N 33/543 (2006.01) G01N 33/68 (2006.01) G01N 33/92 (2006.01)
Patent
CA 2641823
This invention provides novel assays for the detection of dysfunctional HDL. The assays are good diagnostics and/or prognostics for atherosclerosis or other pathologies characterized by an inflammatory response. In certain embodiments the methods involve measurements of heme-related HDL-associated proteins (e.g., haptoglobin, hemopexin, etc.), and/or measurements of the relative distribution of HDL-associated proteins between HDL and the non-lipoprotein fractions of plasma/serum, and/or measurements of the ability of pro-inflammatory HDL to consume nitric oxide, and/or measurement of the ability of HDL to inhibit LDL aggregation.
L'invention concerne de nouveaux dosages pour la détection des lipoprotéines de haute densité dysfonctionnelle (HDL). Ces dosages constituent de bons diagnostics et/ou pronostics pour et d'autres maladies caractérisées par une réaction inflammatoire. Dans certains modes de réalisation, ces méthodes consistent à mesurer les protéines associées à HDL et aux hèmes (p. ex., l'haptoglobine, l'hémopexine, etc.) et/ou à mesurer la répartition relative des protéines associées à HDL entre HDL et les fractions non-lipoprotéiniques de plasma/sérum et/ou à mesurer la capacité de HDL pro-inflammatoire à consommer le monoxyde d'azote et/ou à mesurer la capacité de HDL à inhiber l'agrégation des lipoprotéines de basse densité (LPL).
Fogelman Alan M.
Reddy Srinivasa T.
Cassan Maclean
The Regents Of The University Of California
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