Assessing congestive heart risk in patients treated or...

G - Physics – 01 – N

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G01N 33/68 (2006.01)

Patent

CA 2698899

Methods are provided for assessing a patient being treated with a peroxisome - proliferator-activator-receptor-.gamma. (PPAR-.gamma.) agonist or a thiazolidinedione (TZD), or having a condition treatable with a peroxisome-proliferator-activator-receptor-.gamma. agonist or a thiazolidinedione. Methods include measuring a galectin-3 concentration or a change in a galectin-3 concentration in a body fluid of a patient being treated with a peroxisome-proliferator-activator- receptor-.gamma.agonist or a thiazolidinedione. A comparison to galectin-3 levels or changes in comparable patients provides information indicative of congestive heart risk.

L'invention concerne des méthodes d'évaluation d'un patient traité ou souffrant d'un état susceptible d'être traité avec un agoniste du récepteur gamma activé par les proliférateurs des peroxysomes (PPAR-?) ou avec un thiazolidinedione (TZD). Ces méthodes consistent à mesurer une concentration de la galectine 3 ou une variarion de la concentration de la galectine 3 dans un liquide organique d'un patient traité avec un agoniste du récepteur gamma activé par les proliférateurs des peroxysomes ou avec un thiazolidinedione. Une comparaison des taux ou des variarions de la galectine 3 chez des patients comparables fournit des informations indiquant un risque d'insuffisance cardiaque congestive.

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