Assessment of blood-brain barrier disruption

Details Assessment of blood-brain barrier disruption Assessment of blood-brain barrier disruption

A - Human Necessities

61

B

A61B 5/055 (2006.01) G01R 33/483 (2006.01) A61K 49/00 (2006.01)

Patent

CA 2687106

A method of analyzing a blood-brain barrier of a subject is disclosed. A detectable dose of an MRI contrast agent is administered to the subject, and a plurality of magnetic resonance images of the subject's brain are acquired over a predetermined time-period. Two or more of the magnetic resonance images are compared thereamongst so as to determine variations in concentration of the contrast agent in the brain, and blood-brain barrier function is assessed based on the variations.

L'invention concerne un procédé d'analyse d'une barrière hémato-encéphalique d'un sujet. Une dose détectable d'un agent de contraste d'IRM est administrée au sujet, et une pluralité d'images par résonance magnétique (IRM) du cerveau du sujet est acquise sur une période de temps prédéterminée. Deux ou plus des images par résonance magnétique sont comparées entre elles de façon à déterminer des variations dans la concentration de l'agent de contraste dans le cerveau, et une fonction de barrière hématoencéphalique est évaluée sur la base des variations.

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