A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/502 (2006.01) A61K 31/34 (2006.01) A61P 9/00 (2006.01)
Patent
CA 2646266
The invention provides methods for treating various indications and diseases in a patient in need thereof, wherein the patient has a C825T polymorphism in the G protein beta3 subunit (GNB3), comprising administering to the patient (i) at least one antioxidant compound or a pharmaceutically acceptable salt thereof; (ii) at least one nitric oxide enhancing compound; and (iii) optionally the best current therapy for the treatment of cardiovascular diseases. In one embodiment the antioxidant is a hydralazine compound or a pharmaceutically acceptable salt thereof and the nitric oxide enhancing compound is isosorbide dinitrate and/or isosorbide mononitrate.
L'invention concerne des méthodes destinées au traitement de divers signes et maladies chez un patient nécessitant un tel traitement, le patient possédant un polymorphisme C825T dans la sous-unité bêta 3 de la protéine G (GNB3). Ces méthodes consistent à administrer au patient (i) au moins un composé antioxydant ou un de ses sels de qualité pharmaceutique; (ii) au moins un composé augmentant le taux de monoxyde d'azote; et (iii) éventuellement le meilleur traitement existant pour le traitement de maladies cardio-vasculaires. Dans un mode de réalisation, l'antioxydant est un composé d'hydralazine ou un de ses sels de qualité pharmaceutique et le composé augmentant le taux de monoxyde d'azote est du dinitrate d'isosorbide et/ou du mononitrate d'isosorbide.
Mcnamara Dennis M.
Sabolinski Michael
Tam Sang W.
Worcel Manuel
Bennett Jones Llp
Nitromed Inc.
University Of Pittsburgh Of The Commonwealth System Of Higher Ed
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