Assessment of neurons in the arcuate nucleus to screen for...

C - Chemistry – Metallurgy – 12 – Q

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C12Q 1/02 (2006.01) A61K 38/22 (2006.01) G01N 33/566 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2461454

Screening methods of use in identifying agents that affect caloric intake, food intake, appetite, and energy expenditure are disclosed herein. These methods are used to identify agents of use in treating obesity, or that can be used to decrease the weight of a subject. These methods can also be used to identify agents of use in treating anorexia or cachexia and can be used to increase appetite and to increase the weight and lean body mass of a subject.

L'invention concerne des méthodes de criblage utilisées pour identifier des agents qui modifient l'apport calorique, le régime alimentaire, l'appétit et la dépense énergétique. On applique ces méthodes pour identifier des agents utilisés pour traiter l'obésité ou qui peuvent être utilisés pour réduire le poids du sujet. On peut également utiliser ces méthodes pour identifier des agents utilisés pour traiter l'anorexie ou la cachexie ou pour stimuler l'appétit et la prise de poids et développer la masse maigre chez le sujet.

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