Association between markers in the leptin gene and carcass...

C - Chemistry – Metallurgy – 12 – Q

Patent

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C12Q 1/68 (2006.01)

Patent

CA 2600677

The invention provides a method for sub grouping animals according to genotype wherein the animals of each sub-group have a similar polymorphism or combination of polymorphisms in the leptin gene, the single nucleotide polymorphisms being selected from the group consisting of UASMSl, UASMS2, UASMS3, EXON2-FB, and E2JW. The combination of single nucleotide polymorphisms of the leptin gene, especially combinations comprising alleles of the E2JW locus, may also indicate an increase in the tenderness of meat as well as indicating the quality of other traits of the animals. The invention also provides methods for identifying an animal having a desirable phenotype relating to certain feed intake, growth rate, body weight, carcass merit and composition, and milk yield, as compared to the general population of animals of that species, comprising determining the presence of a single nucleotide polymorphism or combination of single nucleotide polymorphisms in the leptin gene of the animal.

L'invention concerne un procédé destiné à créer des sous-groupes d'animaux en fonction du génotype, les animaux de chaque sous-groupe possédant un polymorphisme similaire ou une combinaison de polymorphisme dans le gène de leptine. Les polymorphismes nucléotide unique étant choisis dans le groupe constitué de UASMS1, UASMS2, UASMS3, EXON2-FB et E2JW. La combinaison de polymorphismes nucléotide unique du gène de leptine, notamment des combinaisons contenant des allèles du locus E2JW, peut également indiquer une augmentation de la tendreté de la viande ainsi que la qualité d'autres caractéristiques de l'animal. L'invention concerne également des procédés destinés à identifier un animal possédant un phénotype souhaitable en fonction de certaines ingestions alimentaires, taux de croissance, poids corporel, vertu de carcasse et composition, et production laitière, par rapport à la population générale d'animaux de cette espèce, qui consiste à déterminer la présence d'un polymorphisme de nucléotide unique ou une combinaison de polymorphismes de nucléotide unique dans le gène de leptine de l'animal.

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