C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) A61K 38/17 (2006.01) C07K 14/47 (2006.01) C12N 5/10 (2006.01) C12N 15/11 (2006.01) C12Q 1/68 (2006.01) G01N 33/68 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2180426
The invention provides genetic suppressor elements that confer upon a cell resistance to one or more chemotherapeutic drug, methods for identifying and obtaining such elements, and methods of using such elements. The invention also provides cloned genes associated with sensitivity to chemotherapeutic drugs, particularly a cloned human kinesin heavy chain gene involved in resistance to DNA damaging agents,
L'invention porte sur des éléments génétiques suppresseurs qui rendent une cellule résistante à un ou plusieurs médicaments de chimiothérapie et sur des méthodes d'identification, d'obtention et d'utilisation de tels éléments. L'invention porte également sur des gènes clonés associés à la sensibilité à des médicaments de chimiothérapie, et en particulier sur un gène à chaîne lourde, cloné par une kinésine humaine, et participant à la résistance envers les agents destructeurs de l'ADN.
Gudkov Andrei
Roninson Igor B.
Mbm & Co.
The Board Of Trustees Of The University Of Illinois
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