Association of polymorphic kinase anchor proteins with...

C - Chemistry – Metallurgy – 12 – Q

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C12Q 1/68 (2006.01) A61B 5/0468 (2006.01) G01N 33/68 (2006.01) G06F 17/00 (2006.01)

Patent

CA 2518238

Polymorphic A-kinase anchor proteins (AKAPs) and nucleic acids encoding the proteins are provided herein. Methods of detecting polymorphic AKAPs and nucleic acids encoding the AKAPs, and kits for use in the detection methods are also provided. Further provided herein are methods of identifying subjects having or at risk of developing diseases or disorders, such as those related to signal transduction and/or cardiovascular disease. Methods of determining susceptibility to morbidity and/or increased or early mortality are also provided.

La présente invention a trait à des protéines polymorphes d'ancrage de la kinase A et des acides nucléiques codant pour ces protéines. L'invention a également trait à des procédés de détection de protéines polymorphes d'ancrage de la kinase A et des acides nucléiques codant pour les protéines polymorphes d'ancrage de la kinase A, et des trousses destinés à être utilisées dans les procédés de détection. L'invention a trait en outre à des procédés d'identification de sujets atteints ou à risque de développer des maladies ou troubles, tels que ceux liés à la transduction de signal et/ou de maladie cardio-vasculaire. Enfin, l'invention a trait à des procédés de détermination de la susceptibilité à la morbidité et/ou la mortalité accrue ou prématurée.

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