C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/68 (2006.01)
Patent
CA 2579885
The invention concerns methods of identifying an increase in risk for coronary heart disease in an individual, wherein the presence of another amino acid than Glutaminic Acid at position 23 and/or the presence of another amino acid than Valine at position 337 in the Kir6.2 protein is determined in a sample. Moreover, probes, primers, polypeptides or polynucleotides suitable for said methods are claimed.
L'invention concerne de méthodes d'identification d'une augmentation de risque de coronaropathie chez un individu. Dans ces méthodes, on identifie la présence d'un acide aminé différent de l'acide glutaminique en position 23 et/ou la présence d'un acide aminé autre que la valine en position 337 dans la protéine Kir6.2, dans un échantillon. En outre, l'invention concerne des sondes, des amorces, des polypeptides ou des polynucléotides appropriés pour des telles méthodes.
Deleuze Jean-Francois
Goegelein Heinz
Jacobs Martina
Kozian Detlef
Mace Sandrine
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Sanofi-Aventis Deutschland Gmbh
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