Associations of polymorphisms in the frzb gene with...

C - Chemistry – Metallurgy – 12 – Q

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C12Q 1/68 (2006.01)

Patent

CA 2521329

Methods and reagents for determining sequence variants present at the FRZB locus, which facilitate identifying individuals at risk for obesity and/or osteoporosis, are provided. In particular, methods for detecting an individual's risk for obesity and/or osteoporosis by detecting at least one polymorphism (e.g., at least one single nucleotide polymorphism) in the FRZB gene in a nucleic acid sample from the individual are provided. Related kits, arrays and systems are also described.

L'invention concerne des méthodes et des réactifs permettant de détecter des variants de séquences présents au niveau du locus FRZB, facilitant l'identification d'individus présentant un risque d'obésité et/ou d'ostéoporose. Ces méthodes permettent plus particulièrement de détecter le risque d'un individu de développer une obésité et/ou une ostéoporose. Ces méthodes consistent à détecter au moins un polymorphisme (au moins un polymorphisme simple nucléotide, par exemple) dans le gène FRZB, dans un échantillon d'acide nucléique prélevé sur l'individu. L'invention concerne également des kits, des réseaux et des systèmes associés.

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