Asthma associated factors as targets for treating atopic...

C - Chemistry – Metallurgy – 07 – J

Patent

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Details

C07J 43/00 (2006.01) A61K 31/56 (2006.01) A61K 31/575 (2006.01) A61K 31/58 (2006.01) A61P 11/06 (2006.01) A61P 37/08 (2006.01) C07J 17/00 (2006.01) C07J 41/00 (2006.01) C07J 51/00 (2006.01) G01N 33/48 (2006.01) G01N 33/50 (2006.01)

Patent

CA 2393135

This invention relates to methods for treating asthma or allergy in a mammal by administering a 3-aminosteroid compound to a mammal in need thereof. The 3-aminosteroid compound being capable of down regulating the IL-9 pathway and alleviating asthmatic responses to allergen. Exemplary 3-aminosteroid compounds used in the methods of the invention include compounds having the chemical formula (I), wherein X, R1, R2, R3, and R4 groups are as defined herein. The invention also relates to certain novel compound of formula (I). Moreover, the invention also provides methods for identifying an immunomodulatory 3-aminosteroid compound.

L'invention concerne des méthodes de traitement de l'asthme ou d'une allergie chez un mammifère, par administration d'un composé 3-aminostéroïde. Ce composé 3-aminostéroïde est capable de réguler à la baisse la voie de passage de IL-9 et de soulager les réponses asthmatiques à l'allergène. Des composés 3-aminostéroïdes exemplaires utilisés dans lesdites méthodes comprennent des composés représentés par la formule chimique (I), dans laquelle des groupes X, R<1>, R<2>, R<3> et R<4> sont définis dans le descriptif. L'invention concerne également un nouveau composé représenté par la formule (I). L'invention concerne enfin des méthodes permettant d'identifier un composé 3-aminostéroïde immunomodulateur.

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