Asthma associated factors as targets for treating atopic...

C - Chemistry – Metallurgy – 07 – K

Patent

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C07K 14/82 (2006.01) A61K 38/17 (2006.01) C07K 14/47 (2006.01) C07K 16/32 (2006.01) C12N 15/11 (2006.01) C12N 15/12 (2006.01) C12Q 1/68 (2006.01) G01N 33/53 (2006.01) G01N 33/574 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2302782

A new gene in the Ras family that is induced by IL-9, thereby providing a therapeutic target in IL-9 mediated development of atopic allergy, asthma- related disorders and certain lymphomas or leukemias. A method for the identification and use of small molecule inhibitors of Ras to treat these disorders. A method for diagnosing susceptibility to, and assessing treatment of atopic allergy, asthma-related disorders and certain lymphomas and leukemias by measuring the level of Ras in biologic samples using antibody specific for the Ras protein.

L'invention concerne un nouveau gène dans la famille Ras qui est induit par le gène IL-9 et constitue une cible thérapeutique dans le développement à médiation génétique IL-9 de l'allergie atopique, des troubles liés à l'astme et de certains lymphomes ou certaines leucémies. L'invention traite aussi d'un procédé pour identifier et utiliser des inhibiteurs de petites molécules de Ras pour traiter ces troubles. L'invention a aussi pour objet un procédé pour diagnostiquer et traiter la prédisposition à l'allergie topique, aux troubles liés à l'asthme eà certains lymphomes ou certaines leucémies en mesurant le taux de Ras dans les échantillons biologiques à l'aide d'anticorps spécifique à la protéine de Ras.

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