C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/24 (2006.01) A61K 31/7088 (2006.01) A61K 38/20 (2006.01) A61K 39/395 (2006.01) A61K 45/00 (2006.01) A61P 11/06 (2006.01) C07H 21/02 (2006.01) C07K 14/54 (2006.01) C07K 16/24 (2006.01) C12N 5/10 (2006.01) C12N 15/11 (2006.01) C12Q 1/00 (2006.01) C12Q 1/68 (2006.01) G01N 33/50 (2006.01) G01N 33/53 (2006.01) G01N 33/543 (2006.01) A61K 48/00 (2006.01)
Patent
CA 2666298
A C to T DNA variation at position 3365 in exon 5 of the human Asthma Associated Factor 1(AAF1) produces the predicted amino acid substitution of a methionine for a threonine at codon 117 of AAF1. When this substitution occurs in both alleles in one individual, it is associated with less evidence of atopic allergy including asthma, fewer abnormal skin test responses, and a lower serum total IgE. Thus, applicant has identified the existence of a non-asthmatic, non-atopic phenotype characterized by methionine at codon 117 when it occurs in both AAF1 gene products in one individual.
Kari Prasad U.
Levitt Roy Clifford
Maloy W. Lee
Nicolaides Nicholas
Genaera Corporation
Ridout & Maybee Llp
LandOfFree
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