Asthma associated factors as targets for treating atopic...

A - Human Necessities – 61 – K

Patent

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Details

A61K 38/16 (2006.01) A61P 11/06 (2006.01) C07K 14/435 (2006.01) C07K 14/47 (2006.01) C07K 16/18 (2006.01) C07K 16/24 (2006.01) C12N 15/12 (2006.01) C12N 15/70 (2006.01) C12N 15/74 (2006.01) C12N 15/79 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2370821

A novel TH2 associated gene that is induced by IL-9 has been identified and isolated, thereby providing a therapeutic target for IL-9 mediated diseases such as atopic allergy and asthma-related disorders. The invention also includes methods for the identification and use of small molecule inhibitors of this gene and its products to treat these disorders, methods for diagnosing susceptibility to, and assessing treatment of atopic allergy or asthma-related disorders by measuring the level of gene expression in biologic samples using antibody specific for this protein. The use of this protein as a therapeutic agent for the treatment of autoimmune diseases is also indicated.

La présente invention concerne un gène associé TH2 induit par IL9, qui a été identifié et isolé, fournissant ainsi une cible thérapeutique destinée aux maladies induites par IL-9, telles que l'allergie atopique et les pathologies liées à l'asthme. Cette invention concerne aussi des techniques d'identification et utilise des inhibiteurs de petites molécules de ce gène et ses produits de façon à traiter ces pathologies, des méthodes permettant de diagnostiquer une sensibilité, et des traitements d'évaluation d'allergie atopique ou de pathologies liées à l'asthme, consistant à mesurer le niveau d'expression génique dans des échantillons biologiques par l'utilisation d'un anticorps spécifique de cette protéine. L'utilisation de cette protéine comme agent thérapeutique destiné au traitement des maladies auto-immune convient également.

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