Asymmetric chemical synthesis and intermediates for making...

C - Chemistry – Metallurgy – 07 – C

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C07C 49/807 (2006.01) C07C 33/46 (2006.01) C07C 49/80 (2006.01) C07D 233/60 (2006.01) C07D 249/08 (2006.01) C07D 303/08 (2006.01) C07D 309/12 (2006.01) C07D 405/06 (2006.01) C07D 407/12 (2006.01) C07D 409/06 (2006.01) C07D 413/06 (2006.01) C07D 417/06 (2006.01) C07D 473/00 (2006.01) C07D 521/00 (2006.01)

Patent

CA 2065741

2065741 9103451 PCTABS00003 Intermediates of structural formula (II), (III), (IV), (VIII), (XI), or (XII), wherein said compound has an asymmetric center(s) as indicated by the single asterisk (*) and the double asterisk (**) and wherein the compound is substantially free from compound (s) having the same chemical structure but having other absolute stereochemical configurations at the asterisked carbon centers, or a pharmaceutically acceptable salt thereof, wherein Ar represents phenyl, substituted phenyl, 3-thienyl, substituted 3-thienyl, 3-furanyl or substituted 3-furanyl; R represents alkyl or cycloalkyl; R1 represents H or alkyl; X represents chloro, bromo or iodo; X1 represents OH, chloro, bromo, iodo or P1 where P1 represents alkoxy-substituted phenyloxy, benzyloxy, substituted benzyloxy, acyloxy, phenylthio, substituted phenylthio or -NHP2 where P2 is an amino protecting group; and P represents H or a hydroxy protecting group and processes for making chemically pure, enantiomeric antifungal compounds.

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