Asymmetric hydrogenation of .beta.-keto esters

Details Asymmetric hydrogenation of .beta.-keto esters Asymmetric hydrogenation of .beta.-keto esters

C - Chemistry, Metallurgy

07

C

C07C 67/31 (2006.01) C07C 69/675 (2006.01) C07C 69/732 (2006.01)

Patent

CA 2284162

Enantiomerically pure .beta.-hydroxy esters are prepared by a process in which .beta.-keto esters are reacted with hydrogen in the presence of catalysts of the formula LRuX2 where X is halogen, acetate, allyl, methallyl, 2-phenylallyl, perchlorate, trifluoroacetate, tetrafluoroborate, hexafluoroantimonate, hexafluorophosphate, hexafluoroarsenate or trichloroacetate, L is a bidentate phospholane of the formula I Image where B = a bridging link with 1 - 5 carbon atoms between the two phosphorus atoms, R1 = H, C1 - C6-alkyl, aryl, alkylaryl or SiR2 3, R2 = alkyl or aryl, m = 0 or 1, R3 = H or OR4, and R4 = R1, with the proviso that if m= 1 then R3 = H and if m = 0 then R3 .noteq. H.

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