C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 491/048 (2006.01) C07D 491/04 (2006.01)
Patent
CA 2111663
ABSTRACT OF THE DISCLOSURE A process for asymmetric hydrogenation of a dihydrofuroimidazole derivative of the general formula (I): Image I wherein R1 represents a cleavable protective group and R2 represents hydrogen or a cleavable protective group, with hydrogen in the presence of a homogeneous catalyst to produce the corresponding diastereomeric tetrahydrofuroimidazole derivative of the general formula (II): Image II Tetrahydrofuroimidazole derivatives of the general formula II are intermediate products for the production of vitamin (+)-biotin.
Eyer Martin
Fuchs Rudolf
Mcgarrity John
G. Ronald Bell & Associates
Lonza Ltd.
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