Asymmetric hydrogenation of furoimidazole derivatives

C - Chemistry – Metallurgy – 07 – D

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C07D 491/048 (2006.01) C07D 491/04 (2006.01)

Patent

CA 2122511

ABSTRACT OF THE DISCLOSURE A novel process for the asymmetric hydrogenation of a furoimidazole derivative of the general formula: Image I with hydrogen in the presence of a homogeneous catalyst to produce the corresponding diastereomeric dihydrofuroimidazole derivative of the general formula: Image II is described. Dihydrofuroimidazole derivatives of the general formula II are intermediates for the preparation of the vitamin (+)-biotin.

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