Asymmetric lamellar aggregates comprising phospholipids and...

A - Human Necessities – 61 – K

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A61K 9/127 (2006.01) A61K 8/14 (2006.01) A61K 8/70 (2006.01) A61K 47/24 (2006.01)

Patent

CA 2138976

The invention relates to pharmaceutical composi- tions which are incorporated into the skin with the aid of novel microaggregates as carriers. The object of the invention is to make available pharmacological active compounds in a biologically and chemically inert carrier for therapeutic and diagnostic administration to the skin or for systemic administration, and in this way to make deeper penetration into the skin or transdermal transport possible. According to the invention, this is effected by means of a pharmaceutical composition for topical admin- istration, which contains asymmetric lamellar aggregates, consisting of phospholipids, pharmacological active compounds and fluorocarbons or fluorocarbon mixtures, the proportion of fluorocarbon being in the range from 1 to 100 % weight/volume, in a pharmaceutical excipient which is suitable for topical administration. Preparation is effected by emulsification of the appropriate cons- tituents and use in ointments, creams, lotions, pastes, gels, powders or on a dressing or plaster or by means of a spray.

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