Asymmetric synthesis of (-)...

Details Asymmetric synthesis of (-)... Asymmetric synthesis of (-)...

C - Chemistry, Metallurgy

07

C

C07C 217/58 (2006.01) C07C 213/00 (2006.01) C07C 215/68 (2006.01) C07C 215/70 (2006.01) C07D 265/18 (2006.01)

Patent

CA 2220389

An improved synthesis of a highly potent HIV reverse transcription inhibitor (I) is disclosed, involving an acetylide and a trifluoromethyl ketone which produces a chiral product in the presence of a chiral amino alcohol.

L'invention a pour objet la synthèse perfectionnée d'un inhibiteur extrêmement puissant (I) de la transcription inverse du VIH faisant intervenir un acétylure et une cétone de trifluorométhyle pour produire un composé chiral en présence d'un amino-alcool chiral.

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