Asymmetric synthesis of benzoxazinones

Details Asymmetric synthesis of benzoxazinones Asymmetric synthesis of benzoxazinones

C - Chemistry, Metallurgy

07

D

C07D 265/18 (2006.01)

Patent

CA 2275323

The present invention provides novel methods for the asymmetric synthesis of (S)-6-chloro-4-cyclopropylethynyl-4-trifluoromethyl-1,4-dihydro-2H-3,1- benzoxazin-2-one of formula (VI-i) which is useful as a human immunodeficiency virus (HIV) reverse transcriptase inhibitor.

La présente invention concerne de nouveaux procédés de synthèse asymétrique de (S)-6-chloro-4-cyclopropyléthynyl-4-trifluorométhyl-1,4-dihydro-2H-3,1-benzoxazine-2-one représenté par la formule (VI-i), et qui convient particulièrement comme inhibiteur de la transcriptase inverse du virus de l'immunodéficience humaine (VIH).

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