Asymmetric synthesis of furo ¬3,4-c| pyridine derivatives

Details Asymmetric synthesis of furo ¬3,4-c| pyridine derivatives Asymmetric synthesis of furo ¬3,4-c| pyridine derivatives

C - Chemistry, Metallurgy

07

D

167/231, 260/276

C07D 491/048 (2006.01) A61K 31/44 (2006.01) C07D 491/04 (2006.01)

Patent

CA 2021737

The invention relates to a method for the preparation of a non-racemic furo [3,4-c] pyridine derivatives of the formula I (see fig. I) wherein R1, R2 and R3 stand for various substituents, comprising adding a concentrated strong acid to a solution of a non-racemic compound of the formula II (see fig. II) in an amount sufficient to catalyse a deprotection/cyclodehydratation.

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