Asymmetric synthesis of ó-cycloalkylalkyl substituted...

C - Chemistry – Metallurgy – 07 – D

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C07D 213/53 (2006.01) C07C 29/48 (2006.01) C07C 35/28 (2006.01) C07C 45/28 (2006.01) C07C 45/29 (2006.01) C07C 49/433 (2006.01) C07C 49/513 (2006.01) C07C 251/20 (2006.01) C07C 271/12 (2006.01) C07C 317/28 (2006.01) C07C 323/45 (2006.01) C07D 233/64 (2006.01) C07D 271/06 (2006.01) C07D 277/28 (2006.01) C07D 333/22 (2006.01)

Patent

CA 2192417

This invention relates to processes for asymmetrically producing enantiomerically pure .alpha.- cycloalkylalkyl substitututed methanamines from .alpha.-pinene. One key step of the process of this invention utilizes the oxidation product of .alpha.-pinene, hydroxy pinanone, as a chiral auxiliary to direct the stereoselective alkylation of the corresponding ketimine. This invention also relates to key intermediates useful in the processes referred to herein.

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