Asymmetric synthesis of pregabalin

Details Asymmetric synthesis of pregabalin Asymmetric synthesis of pregabalin

C - Chemistry, Metallurgy

07

C

C07C 253/30 (2006.01) C07C 255/19 (2006.01) C07C 255/23 (2006.01)

Patent

CA 2396090

This invention provides a method of making (S)-(+)-3-(aminomethyl)-5- methylhexanoic acid (pregabalin) or a salt thereof via an asymmetric hydrogenation synthesis. Pregabalin is useful for the treatment and prevention of seizure disorders, pain, and psychotic disorders. The invention also provides intermediates useful in the production of pregabalin.

L'invention concerne un procédé de fabrication d'acide (S)-(+)-3-(aminométhyl)-5-méthylhexanoïque (prégabaline), ou un de ses sels, via un synthèse asymétrique par hydrogénation. La prégabaline est utile dans le traitement et la prévention de crises, de douleur et de troubles psychotiques. L'invention concerne aussi des intermédiaires utiles dans la production de prégabaline.

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