Asymmetric synthesis of quinazolin-2-ones useful as hiv...

Details Asymmetric synthesis of quinazolin-2-ones useful as hiv... Asymmetric synthesis of quinazolin-2-ones useful as hiv...

C - Chemistry, Metallurgy

07

D

C07D 239/80 (2006.01)

Patent

CA 2403230

This invention relates generally to the asymmetric synthesis of quinazolin-2- ones that are useful as inhibitors of HIV reverse transcriptase. The synthesis is accomplished through the chiral ligand mediated addition of cyclopropylacetylide.

La présente invention concerne, de manière générale, la synthèse asymétrique de quinazolin-2-ones, qui sont utilisées comme inhibiteurs de la transcriptase inverse du VIH. Ladite synthèse s'effectue par une addition de cyclopropylacétylide médiée par un ligand chiral.

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