C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 323/59 (2006.01) A61B 6/00 (2006.01) A61K 31/17 (2006.01) A61K 51/00 (2006.01) A61P 35/00 (2006.01) C07C 275/16 (2006.01) C07C 275/24 (2006.01) C12Q 1/37 (2006.01) G01N 33/60 (2006.01) G01N 33/62 (2006.01) G01N 33/68 (2006.01)
Patent
CA 2473289
The present invention relates to compounds particularly asymmetric urea compounds which are labeled with one or more radioisotopes and which are suitable for imaging or therapeutic treatment of tissues, organs, or tumors which express NAALADase and/or PSMA. In another embodiment, the invention relates to methods of imaging tissues, organs, or tumors using radiolabeled compounds of the invention, particularly tissues, organs, or tumors which express NAALADase and/or PSMA to which the compounds of the invention have an affinity. In another embodiment, the invention relates to pharmaceutical compositions containing urea compounds.
La présente invention se rapporte à des composés, plus particulièrement à des composés d'urée asymétriques marqués avec un ou plusieurs radio-isotopes et se prêtant à l'imagerie ou au traitement thérapeutique de tissus, d'organes ou de tumeurs exprimant la NAALADase et/ou le PSMA. Selon un autre mode de réalisation, l'invention se rapporte à des procédés d'imagerie de tissus, d'organes ou de tumeurs utilisant des composés radiomarqués, plus particulièrement des tissus, des organes ou des tumeurs exprimant la NAALADase et/ou le PSMA pour lesquels les composés de cette invention ont une affinité. Selon un autre mode de réalisation, l'invention se rapporte à des compositions pharmaceutiques contenant des composés d'urée.
Kozikowski Alan P.
Musachio John L.
Pomper Martin G.
Zhang Jiazhong
Georgetown University
Norton Rose Canada S.e.n.c.r.l.,s.r.l./llp
The John Hopkins University
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