Asymmetrical alkyl diphenylakylaminoalkyl esters of l,...

Details Asymmetrical alkyl diphenylakylaminoalkyl esters of l,... Asymmetrical alkyl diphenylakylaminoalkyl esters of l,...

C - Chemistry, Metallurgy

07

D

167/228, 260/294

C07D 211/90 (2006.01) A61K 31/44 (2006.01) C07C 205/56 (2006.01) C07D 413/04 (2006.01)

Patent

CA 1277666

ABSTRACT Novel antihypertensive and coronary dilating asymmetsic diesters of 1,4-dihydro-2,6-dimethyl-pyridine-3,5-dicarboxylic acid (or the stereoisomers or pharmaceutically acceptable acid addition salts thereof) have the general formula (I): Image (I) wherein Ph is phenyl, Ar is 2-nitrophenyl, 3-nitrophenyl, 2,3-dichlorophenyl or benzofurazan-4-yl, A is a straight or branched chain alkylene radical having from 2 to 6 carbon atoms, R is a straight or branched chain alkyl radical having from 1 to 6 carbon atoms, optionally mono-substituted by an alkoxy substituent having from 1 to 6 carbon atoms, R1 is hydrogen, hydroxy or an alkyl radical having from 1 to b carbon atoms, and R2 is hydrogen or methyl. The subject diesters may be prepared from the aldehydes ArCHO and esters of acetoacetic and 3-aminocrotonic acids.

474009

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