Atmospheric pressure photoionization (appi): a new...

H - Electricity – 01 – J

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H01J 49/04 (2006.01)

Patent

CA 2386832

There is provided a method of, and apparatus for, analyzing a sample of an analyte provided as a sample solution comprising a solvent and an analyte. A dopant is provided, either separately or as the solvent of the sample solution. The sample solution is formed into a spray, for example in a nebulizer, and the solvent evaporated. The sample stream is irradiated in a region at atmospheric pressure, either in the liquid state prior to formation of a spray, or in the liquid state after formation of a droplet spray, or in the vapour state after evaporation of the sprayed droplets, to ionize the dopant. Then, subsequent collisions between the ionized dopant and the analyte, either directly or indirectly, result in ionization of the analyte. Analyte ions are passed from the atmospheric pressure ionization region into a mass analyzer for mass analysis. This technique has been found to give much enchanced inonization for some substances, as compared to atmospheric pressure chemical ionization.

La présente invention concerne un procédé et un dispositif servant à l'analyse d'un échantillon d'analysat en solution dans un solvant. On utilise un dopant, soit séparément, soit comme solvant de la solution d'échantillon. On nébulise la solution d'échantillon, notamment dans un nébuliseur, et on évapore le solvant. Le courant d'échantillon s'irradie dans une zone sous pression atmosphérique, soit à l'état liquide juste avant la formation d'un brouillard, soit à l'état liquide avant la formation d'un brouillard de gouttelettes, soit enfin à l'état de vapeur après l'évaporation des gouttelettes du brouillard, de façon à ioniser le dopant. Par la suite, les collisions entre le dopant ionisé et l'analysat, directement ou indirectement, aboutissent à l'ionisation de l'analysat. On fait passer les ions d'analysat de la zone d'ionisation sous pression atmosphérique à l'analyseur de masse en vue de l'analyse de masse. Il s'est avéré que ce procédé aboutit à une bien meilleure ionisation pour certaines substances que par ionisation chimique sous pression atmosphérique.

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