Atomoxetine formulations

A - Human Necessities – 61 – K

Patent

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Details

A61K 31/135 (2006.01) A61K 9/00 (2006.01) A61K 9/10 (2006.01) A61K 9/16 (2006.01) A61K 9/28 (2006.01) A61K 9/48 (2006.01)

Patent

CA 2552064

The invention provides novel dosage forms of atomoxetine and its salts, particularly atomoxetine hydrochloride including wax dosage forms, press-coat dosage forms, and sprinkle dosage forms, and other novel dosage forms. The invention also provides sustained-release and pulsed-release dosage forms of atomoxetine, and its salts. Methods of making novel atomoxetine dosage forms are given. Methods of treating senile dementias, including Alzheimer's dementia, attention deficit disorder and other neuropsychiatric disorders by administering an effective amount of the dosage forms disclosed herein, either alone or in combination with one or more other medicaments, are also provided by the invention.

L'invention concerne de nouvelles formes posologiques d'atomoxétine et de sels d'atomoxétine, notamment d'hydrochlorure d'atomoxétine, y compris des formes posologiques à base de cire, des formes posologiques revêtues à pression, des formes posologiques à saupoudrer et d'autres nouvelles formes posologiques. L'invention concerne également des formes posologiques à libération prolongée et à libération pulsée d'atomoxétine et de sels d'atomoxétine. L'invention se rapporte en outre à des méthodes destinées à traiter les démences séniles, telles que la démence d'Alzheimer, le trouble déficitaire de l'attention et d'autres troubles neuropsychiatriques, par administration d'une dose efficace des formes posologiques susmentionnées, de manière isolée ou en combinaison avec un ou plusieurs autres médicaments.

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