Atorvastatin hemi-calcium form vii

Details Atorvastatin hemi-calcium form vii Atorvastatin hemi-calcium form vii

C - Chemistry, Metallurgy

07

D

C07D 207/34 (2006.01) A61K 31/40 (2006.01) A61P 3/06 (2006.01) C07D 405/06 (2006.01)

Patent

CA 2426632

The present invention provides a novel form of atorvastatin hemi-calcium designated Form VII and novel processes for its preparation whereby another crystalline form of atorvastatin hemi-calcium is suspended in ethanol, preferably absolute ethanol, and is converted to the new form, which is then isolated. The present invention further provides a method of reducing the plasma low density lipoprotein level in patients suffering from or susceptible to hypercholesterolemia and compositions and dosage forms for practicing the invention.

L'invention concerne une nouvelle forme d'atorvastatine hémicalcique appelée forme VII, et de nouveaux procédés de préparation de celle-ci. Selon ces procédés, une autre forme cristalline d'atorvastatine hémicalcique est suspendue dans de l'éthanol, de préférence de l'éthanol absolu, et est transformée en ladite nouvelle forme, qui est ensuite isolée. L'invention concerne en outre un procédé visant à réduire le taux plasmatique de lipoprotéines de basse densité chez des patients atteints ou susceptibles d'être atteints d'hypercholestérolémie, ainsi que des compositions et des formes posologiques permettant de mettre en oeuvre le procédé.

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