C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) A61K 38/17 (2006.01) C07K 14/705 (2006.01) C07K 16/28 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2344107
Modulation of the activity of transmembrane proteins belonging to the ATP binding cassette (ABC) transporter protein family which are etiologically involved in cholesterol driven atherogenic processes and inflammatory diseases like psoriasis, lupus erythematodes and others provides therapeutic means to treat such diseases. Furthermore, detection of herein identified ABC transporter proteins of their respective biochemical activities involved in such atherogenic and inflammatory processes provides diagnostic means for clinical application of diagnosis and monitoring of dyslipidemias, atherosclerosis or inflammatory diseases like psoriasis and lupus erythematodes.
Selon l'invention, la modulation de l'activité de protéines transmembranaires qui appartiennent à la famille de protéines de transport (ABC) de cassette de liaison avec ATP et sont impliquées de manière étiologique dans des processus athérogènes provoqués par le cholestérol et dans des maladies inflammatoires comme le psoriasis, le lupus érythémateux et autres, constitue un moyen thérapeutique de traiter de telles maladies. En outre, la détection des protéines de transport (ABC) ici identifiées et de leurs activités biochimiques respectives, impliquées dans de tels processus athérogènes et inflammatoires, constitue un moyen de diagnostic destiné à l'application clinique de diagnostic et de surveillance des dyslipidémies, de l'athérosclérose ou de maladies inflammatoires telles que le psoriasis ou le lupus érythémateux.
Klucken Jochen
Schmitz Gerd
Aktiengesellschaft Bayer
Fetherstonhaugh & Co.
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